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HER2(Phospho-Tyr1248) Antibody

11079
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  Catalog No. Package Size Price
11079-1 50ul $189.00
11079-2 100ul $279.00

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Description
  • Product Name HER2(Phospho-Tyr1248) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB IHC IF
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1248.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of tyrosine1248 (P-E-Y(p)-L-G) derived from Human HER2.
  • Target Name HER2
  • Modification Phospho
  • Alternative Names C-erbB-2; ErbB2;
  • Accession No. Swiss-Prot: P04626
    NCBI Protein: NP_001005862.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 185kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

Images
  • HER2(Phospho-Tyr1248) Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HER2 (Phospho-Tyr1248) Antibody #11079 (left) or the same antibody preincubated with blocking peptide #51079 (right).

  • HER2(Phospho-Tyr1248) Antibody - SAB | Signalway Antibody

    Immunofluorescence staining of methanol-fixed MCF7 cells using HER2(Phospho-Tyr1248) Antibody #11079.

  • HER2(Phospho-Tyr1248) Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using HER2 (Phospho-Tyr1248) Antibody #11079.

  • HER2(Phospho-Tyr1248) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from HepG2 cells treated with PMA and MCF cells treated with EGF, using HER2 (Phospho-Tyr1248) Antibody #11079.

Background

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin.

Yuan,Lu Qian ,Ming Shi, et al. (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3 Guogang Cellular Signalling, 20:1284

  • Yuan Guogang, Lu Qian, Ming Shi et al,HER2-dependent MMP-7 expression is mediated by activated STAT3., Cellular Signalling, 20(7):1284¨C1291 (2008),
    PMID: 18411043
  • Please let us know if you have published research using #11079 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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