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Mouse BDNF ELISA Kit

EK5128
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  Catalog No. Package Size Price
EK5128 96T $449.00

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Description
  • Product Name Mouse BDNF ELISA Kit
  • Specificity Mouse
  • Crossing Reactivity There is no detectable cross-reactivity with other relevant proteins.
  • Immunogen Type sf21,H129-R247
  • Alternative Names Brain-derived neurotrophic factor; BDNF; Bdnf;
  • Accession No. P21237
  • Cell Localization Secreted.
Application Details

sensitivity:2pg ml
Detect Range:31.2pg ml-2000pg ml
sample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA citrate).
capture_antibody:monoclonal antibody from rat
detection_antibody:polyclonal antibody from goat
gene_name:BDNF
protein_name:Brain-derived neurotrophic factor
gene_full_name:Brain-derived neurotrophic factor
tissue_specificity:
sequence_similarities:
tmb_incubation:20-25min
research_category:neuroscience|neurology process|growth and development|neurotrophins|neurodegenerative disease|huntington"s disease|alzheimer"s disease|cardiovascular|atherosclerosis|diabetes associated|thrombosis|metabolism|types of disease|diabetes|obesity

Product Description
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse BDNF
Background
protein_function: During development, promotes the survival anddifferentiation of selected neuronal populations of the peripheraland central nervous systems. Participates in axonal growth,pathfinding and in the modulation of dendritic growth andmorphology. Major regulator of synaptic transmission andplasticity at adult synapses in many regions of the CNS.
Brain-derived neurotrophic factor(BDNF) is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. It is a secreted protein with the molecular weight of 27.8kDa, consisting of 247 amino acids. It is known to promote neuronal survival and differentiation. BDNF shares substantial amino acid sequence identity with nerve growth factor(NGF). BDNF and neurotrophin-3(NT-3) are two recently cloned neurotrophic factors that are homologous to NGF. mRNA products of the BDNF and NT-3 genes are detected in the adult human brain, suggesting that these proteins are involved in the maintenance of the adult nervous system. BDNF and other neurotrophins are critically involved in long-term potentiation(LTP). BDNF-mediated LTP is induced postsynaptically. BDNF has trophic effects on serotonergic(5-HT) neurons in the central nervous system. BDNF has an essential maintenance function in the regulation of anxiety-related behavior and in food intake through central mediators in both the basal and fasted state. It plays a role in treating breathing disorders such as respiratory insufficiency after spinal injury. The mature form of BDNF is identical in all mammals examined, and the gene encoding human BDNF to chromosome 11, band p13.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
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    • C Caenorhabditis elegans
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    • RbRabbit
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