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Bub3 Antibody

24534
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  Catalog No. Package Size Price
24534 100ul $390.00

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Description
  • Product Name Bub3 Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Affinity chromatography purified via peptide column
  • Applications ELISA WB ICC
  • Species Reactivity Hu Ms
  • Immunogen Type Peptide
  • Immunogen Description Raised against a 16 amino acid peptide from near the carboxy terminus of human bub3.
  • Target Name Bub3
  • Alternative Names Budding uninhibited by benzimidazoles 3, Bub3L
  • Accession No. O43684
  • Concentration 1mg/ml
  • Formulation Supplied in PBS containing 0.02% sodium azide.
  • Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Images
  • Bub3 Antibody - SAB | Signalway Antibody

    Western blot analysis of bub3 in Jurkat cell lysate with bub3 antibody at (A) 0.5 and (B) 1 ug/mL.

  • Bub3 Antibody - SAB | Signalway Antibody

    Immunocytochemistry of Bub3 in Jurkat cells with Bub3 antibody at 10 ug/mL.

Background
The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.
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    Protocol
    Browsing historyclear
    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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