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STAT3(Phospho-Tyr705) Antibody

11045
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  Catalog No. Package Size Price
11045-1 50ul $189.00
11045-2 100ul $279.00

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Description
  • Product Name STAT3(Phospho-Tyr705) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB IHC IF
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of STAT3 only when phosphorylated at tyrosine 705.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of tyrosine 705 (A-P-Y(p)-L-K) derived from Human STAT3.
  • Target Name STAT3
  • Modification Phospho
  • Alternative Names APRF; Acute-phase response factor; HIES
  • Accession No. Swiss-Prot: P40763
    NCBI Protein: NP_003141.2
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 88kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Images
  • STAT3(Phospho-Tyr705) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from Hela cells untreated or treated with IFN a using STAT3(Phospho-Tyr705) Antibody #11045.

  • STAT3(Phospho-Tyr705) Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT3 (Phospho-Tyr705) Antibody #11045 (left) or the same antibody preincubated with blocking peptide #51045 (right).

  • STAT3(Phospho-Tyr705) Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human Lung carcinoma tissue using STAT3 (Phospho-Tyr705) Antibody #11045.

  • STAT3(Phospho-Tyr705) Antibody - SAB | Signalway Antibody

    Immunofluorescence staining of methanol-fixed MEF cells untreated or treated with IFN using STAT3 (Phospho-Tyr705) Antibody #11045.

Background

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436.
Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178.
Welsh, et al. (1996) Trends Cell Biol. 6: 274-279.
Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141.

  • Feng-Ze Wang, Peng-Jiao, Na-Na Yang et al,PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells, Toxicology Letters, 220:150¨C 156 (2013),
    PMID: 23639247
  • Libing Ma, Jinxiu Li, Guyi Wang et al,Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K¨CAkt signaling pathways., Regulatory Peptides., 181:9¨C16 (2013),
    PMID: 23327998
  • Emilio Garc¨ªa-Prieto, Adri¨¢n Gonz¨¢lez-L¨®pez, Sandra Cabrera et al,Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10. , PLoS ONE, 5(10): e13242 (2010),
    PMID: 20949050
  • Jian-Guo Zhang, Jing Zhao, Yan Xin et al,Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions., World J Gastroenterol, 16(5): 571¨C577. (2010),
    PMID: 20128024
  • Takuya Takeichi, Kazumitsu Sugiura, Yoshinao Muro et al,Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that Seen in the Psoriatic Condition., Journal of Investigative Dermatology, 130(12):2760-2767 (2010),
    PMID: 20631726
  • H Yamaguchi, J Zhu, T Yu et al,Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation., Toxicology, 226:131-142 (2006),
    PMID: 16860915
  • Please let us know if you have published research using #11045 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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